Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data

Journal of Isotopes > 2004 > 17(2): 69-69.

Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data[J]. Journal of Isotopes, 2004, 17(2): 69-69.

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Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data[J]. Journal of Isotopes, 2004, 17(2): 69-69.

Citation:

Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data[J]. Journal of Isotopes, 2004, 17(2): 69-69.

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Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data

TANG Gang-hua~1, TANG Xiao-lan~2, WANG Ming-fang~1, LUO Lei~1, GAN Man-quan~1 (1. Nanfang PET Centre, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China

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Received Date: February 26, 2003

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Abstract

To estimate the human radiation absorbed doses of O-(2-~(18)F-fluoroethyl)-L-tyrosine (FET), mice are considered as model. FET is injected into mice through a tail vein. At 10, 30, 60, 120 and 180 min after injection, the mice are killed by cervical fracture and the biodistribution in mice are determined. Human dosimetric estimation is performed from the biodistribution of FET in mice and the standard Medical Internal Radiation Dose (MIRD) method using time - fractional radioactivity curves for humans. The bone in human is the organ receiving highest dose of 4.78 pGy/Bq, the brain and the whole body receive the lowest dose of 1.6 pGy/Bq, and other organs receive doses between 1.6 and 3.5 pGy/Bq. The effective dose is estimated to be 9.0 pSv/Bq. The data show that a 370 MBq injection of FET leads to an estimated effective dose of 3.3 mSv, which is in the range of routine nuclear medicine investigations. The potential radiation risks associated with this study are well within accepted limits.
- O-(2-~(18)F-Fluoroethyl)-L-tyrosine(FET),
- mice,
- biodistribution,
- radiation absorbed dose

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[1]	WesterHJ,HerzM,WeberW,etal.SynthesisandRadiopharmacologyofO-(2-[18F]fluoroeth-yl)-L-tyrosineforTomorImaging[J].JNuclMed,1999,40(1):205～212.
[2]	HeissP,MayerS,HerzM,etal.InvestigationofTransportMechanismandUptakeKineticsofO-(2-[18F]fluoroethyl)-L-tyrosineinVitroandinVivo[J].JNuclMed,1999,40(8):1367～1373.
[3]	WeberWA,WesterHJ,GrosuAL,etal.O-(2-[18F]fluoroethyl)-L-tyrosineandL-[methyl-11C]methionineUptakeinBrainTumours:InitialRe-sultsofaComparativeStudy[J].EurJNuclMed,2000,27(5):542～549.
[4]	朴日阳,崔瑞雪,杜宜奎,等.O-(2-18F-氟代乙基)-L-酪氨酸的合成及初步动物实验[J].中华核医学杂志,2000,20(6):272～273.
[5]	TaylorDM.GenericModelsforRadionuclideDo-simetry:11C-,18F-or75Se-labelledAminoAcids[J].ApplRadiatIsot,2000,52(3):911～922.
[6]	PauleitD,FloethF,HerzogH,etal.Whole-bodyDistributionandDosimetryofO-(2-[18F]fluoroethyl)-L-tyrosine[J].EurJNuclMedMolImaging,2003,30(4):519～524.
[7]	TangGanghua,TangXiaolan,WangMingfang,etal.AutomatedCommercialSynthesisSystemforPreparationofO-(2-[18F]fluoroethyl)-L-tyro-sinebyDirectNucleophilicDisplacementonaResinColumn[J].JLabelledCompdRadio-pharm,2003,46(7):661～668.
[8]	唐刚华,王明芳,唐小兰,等.O-(2-18F-氟代乙基)-L-酪氨酸的合成改进及其动物实验研究[J].亚洲核医学杂志,2002,2(2):90～92.
[9]	SynderWS,FordMR,WarnerGG,etal."S"AbsorbedDosePerUnitCumulatedActivityforSelectedRadionuclidesandOrgans[S].MIRDPamphlet11.NewYork,1975.
[10]	KirschnerA,IceR,BeierwaltersW.RadiationDosimetryof131I-19-iodocholesterol:thePitfallsofUsingTissueConcentrationData,theAuthor'sReply[J].JNuclMed,1975,16(1):248～249.
[11]	DeGradoTR,ReimanRE,PriceDT,etal.Ph-armacokineticsandRadiationDosimetryof18F-fluorocholine[J].JNuclMed,2002,43(1):92～96.
[12]	唐刚华,唐小兰,王明芳,等.由动物实验估算18F-FDG在人体内的辐射吸收剂量[J].中华放射医学与防护医学杂志,2001,21(3):207～209.
[13]	唐刚华,张岚,唐小兰,等.由大鼠体内分布估算6-18F-L-多巴在人体内的吸收剂量[J].同位素,2002,15(3):164～167.
[14]	DeterdingTA,VotawJR,WangCK,etal.Bi-odistributionandRadiationDosimetryoftheDopamineTransporterLigand[18F]FECNT[J].JNuclMed,2001,42(2):376～381.
[15]	国际放射防护委员会第53号出版物.放射性药物对患者产生的辐射剂量[R].北京:原子能出版社,1991.1～29.
[16]	唐刚华,姜国辉,郑连芳.稳定同位素结合GC-MS法测定大鼠体内川芎哚的药物动力学参数[J].中国药理学报,2000,21(6):660～662.
[17]	BrownWD,OakesTR,DeJesusOT,etal.Flu-orine-18-fluoro-L-DOPADosimetryWithCar-bidopaPretreatment[J].JNuclMed,1998,39(11):1884～1891.
[18]	MejiaAA,NakamuraT,MasatoshiI,etal.Es-timationofAbsorbedDosesinHumansDuetoIntravenousAdministrationofFluorine-18-fluo-rodeoxyglucoseinPETStudies[J].JNuclMed,1991,32(4):699～706.
[19]	CoffeyJL,WatsonEE.CalculationDoseFromRemainingBodyActivity:aComparisonofTwoMethods[J].MedPhys,1979,6(4):307～308.

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Human Dosimetric Estimation of O-(2-~(18)F-fluoroethyl)-L-tyrosine Based on Mice Biodistribution Data

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