Experimental Studies of Prevention of TIPSS Shunt Stenosis With Low Dose ~(103)Pd Stents

To evaluate the role about prevention of shunt stenosis after TIPSS by ~(103)Pd stents, ~(103)Pd stents and general stents are placed respectively in 18 healthy swines which in the two groups at 4, 8 weeks after TIPSS, are made angiography, pathological dissection and inspection of lumen area by light microscope. The results show that stenosis appears in 2 cases of radiation group and 3 cases in control group at 4 weeks. Obstructon appears in all of radiation group and partly stenosis appeared in 2 cases of radiation group and 3 cases in control group at 4 weeks. and in all of radiation group and partly stenosis appears in control group at 8 weeks. Thickness of vascular wall of hepatic vein segment in scope of stents is 3.64±1.01 mm in radiation group(12.95 MBq) and 2.24±(1.02) mm in control group. Difference between two groups is evidenced (P<0.05). 9.25 and 12.95 MBq~(103)Pd stents can not prevent stenoses after TIPSS.