Citation: | HOU Xingguo, WANG Feng, DING Jin, ZHU Hua, YANG Zhi. Preparation of 124I, Antibody Labeling and Micro-PET/CT Imaging of Labeled Compounds[J]. Journal of Isotopes, 2024, 37(4): 387-393. DOI: 10.7538/tws.2023.youxian.101 |
To provide a method for the production of 124I by using a medical cyclotron and the method of 124I labeling, 124I was prepared using a nuclear reaction of 124Te (p, n) 124I. Firstly, a 124TeO2/Al2O3 target was obtained by pressing, and then bombarded with a cyclotron for 3-8 hours. After 12 hours, impurity nuclides produced by the side reaction were removed. Finally, a Na124I solution was obtained by iodine sublimation radiochemical separation method. Analyze the purity of Na124I and label it with anti-mesothelin (MSLN) antibody, then inject it into the tail vein of KM mice to observe the distribution of 124I-anti-MSLN. The obtained 124TeO2/Al2O3 target was bombarded with 12.5 MeV energy and 20 μA proton beam to obtain 340.4-
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