Automated Synthesis and Preliminary Clinical Application of 18F-Florbetabe
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Abstract
18F-florbetaben is of great value in the diagnosis of Alzheimer’s diseases. In this study, a simple and reliable process for the automated production of 18F-florbetaben was established by using improved domestic fluorine multifunctional modules, and preliminary clinical studies were carried out to validate the clinical application value. Results show that the automated synthesis of 18F-florbetaben takes 38 minutes, the no-corrected synthesis efficiency is (45.0±2.3)% (n=6), and the radiochemical purity is more than 95%. Results of human PET show that 18F-florbetaben is effective for Alzheimer’s diseases. All these results confirm that, the process for the automated synthesis of 18F-florbetaben using domestic fluorine multifunctional module is concise, reliable and reproducible, also the quality fully meets the clinical requirements. Our results can promote the domestic applications of 18F-florbetaben.
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