The Research Progress of ⁶⁸Ga Generator and ⁶⁸Ga Radiopharmaceuticals

Positron emission tomography (PET) is an important diagnosis and imaging tool for nuclear medicine, and playing an increasing part in fundamental medicine, new drug research and clinical effect assessment, etc. ¹⁸F is the most common radionuclide for PET imaging, which is produced in a cyclotron. ⁶⁸Ga is a PET imaging radionuclide of increasing concern, and is gained from long-lived ⁶⁸Ge/⁶⁸Ga generator systems. The use of ⁶⁸Ga does not demandan on-site cyclotron, which provide a convenient method for researchers. With the development of coordination chemistry, a variety of bifunctional chelators have been developed for ⁶⁸Ga labeling, which allow the convenient coupling tomany chemical structures and biomolecules. Kitformulated preparation is another advantage for ⁶⁸Ga radiopharmaceuticals. This review presents the developments of the ⁶⁸Ga based radiopharmaceuticals.