Positron Emission Radiometals ⁶⁴Cu, ⁶⁸Ga, ⁸⁶Y and ⁸⁹Zr Labeled PET Drugs

Positron emission radiometals ⁶⁴Cu, ⁶⁸Ga, ⁸⁶Y and ⁸⁹Zr have different half lives and special biological properties, not only enrich the diversity of PET drugs, but also provide a new opportunity for the diagnosis and treatment of disease. In recent years, positron emission radiometals ⁶⁴Cu, ⁶⁸Ga, ⁸⁶Y and ⁸⁹Zr have more and more applications in the medical diagnostics of PET (positron emission tomography). ⁶⁴Cu has already had a significant impact in cancer hypoxia imaging. ⁶⁸Ga is developing rapidly in the field of diagnosis of NET (Neuroendocrine tumor) tumor. ⁸⁹Zr and ⁸⁶Y are expected to play a role in the field of immunoPET and radioimmunotheray. This paper briefly reviews the research progress on the production and purification, solution coordination chemistry and applications of ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr and ⁶⁴Cu.