Rapid Detection of Bacterial Endotoxin Content in ¹⁸F-FDG Injection

The American Endosafe-PTS detector of bacterial endotoxin was used to detecte ⁸F-FDG injection, and the results were compared to traditional spectrophotometric determination. Meanwhile, the impacts on the content of bacterial endotoxin caused by new production and high radio-dose of ¹⁸F-FDG was also evaluated by PTS detection. The results showed that recovery rates were about 50% to 200%, detecting contents were smaller than 5 EU/mL, both of which conformed to the rules of ¹⁸F-FDG in Chinese Pharmacopeia. The detecting results were consistent between PTS and traditional spectrophotometric detection, which indicated the trustworthiness and reliability for PTS detecttion. The consistence before and after radiative decay of new production and high radiodose of ¹⁸F-FDG indicated that radiactive rays had no impacts on the content of bacterial endotoxin. The results reveal that PTS-based detection of bacterial endotoxin content is a rapid and effective approach for ¹⁸F-FDG injection.