Preparation and Biological Evaluation of Novel 18F-labeled Phosphonuim Cation for Myocardial Perfusion Imaging with PET
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Abstract
In order to develop new PET myocardial perfusion imaging agent, a novel 18F labeled phosphonium cation: (3-(18Ffluoromethyl)benzyl) tris (2, 6-dimethoxyphenyl) phosphonium salt, 18F-2, had been designed and prepared. Biological evaluation of 18F-2 had been performed in Kunming normal mice. 18F-2 was obtained by a simple one-pot method and the radiochemical yield was (31±3)%. The total radio-synthesis time was less than 60 min and the radiochemical purity of final radiotracer was more than 95%. The biodistribution of 18F-2 displayed a high heart uptake and good retention. The heart uptake of 18F-2 at 5 and 60 min post-injection were (53.88±7.45)%ID/g and (23.93±3.28)%ID/g, respectively. 18F-2 exhibited low radio-accumulation in non-target tissues and rapid clearance in liver, lung and blood. The heart to liver, heart to lungs and heart to blood ratio values were 3.99, 3.80 and 9.17, respectively. The results indicated that 18F-2 could be as a promising myocardial perfusion imaging agent for PET imaging.
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