Syntheses of Labeled Dimethyl Phthalate-D₆

The synthesis of labeled standard dimethyl phthalate-D₆，with CD3OD and benzene anhydride as raw materials by an efficient and no-dilution of isotopic enrichment method was presented, under the catalysis of condensing agent to generate dimethyl phthalate-D₆。The yield of dimethyl phthalate-D₆ was 88.0% based on CD₃OD consumed．The product was confirmed by NMR and MS to be target compound．Its chemical purity was 99.0% and isotopic enrichment was 99.1 atom % D．The result showed that It could be used as internal standard in the field of food safety testing．