Labeling and Imaging Study of Fatty Acid Analogue ¹⁸F-FHTA on Domestic Synthesis Module

¹⁸F-6-thia-14-fluoro-heptadecanoic acid (¹⁸F-FTHA), a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production, a study was performed on domestic synthesis module. Methods: ¹⁸F-FTHA was prepared from Benzyl-14-tosyloxy-6-thia-heptadecanoate as precursor. Biodistribution studies in the NH rats and Micro-PET/CT imaging studies in the SD rat were performed. The results showed that total synthesis time was about 50 minutes and the uncorrected synthesis yield was 10.6%, radiochemical purity was higher than 99%, the product had good stability at room temperature. Biodistribution data in rats showed the uptake of heart was 19.04 ID%/g at 60 minutes, heart-to-liver ratios at 60 and 90 min were 6.4 and 3.2, respectively. Micro-PET/CT imaging of the SD rat showed intense cardiac uptake. Conclusions: Using this procedure a fast, reliable, automated synthesis for the myocardial PET tracer, ¹⁸F-FTHA, can be obtained.