Progress of the Methods for 18F-labeled Peptides
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Abstract
With the wide use of positron emission tomography (PET) imaging for the detection of cancer, neurological diseases, and cardiovascular diseases, peptides labeled with positron-emitting radionuclide (18F) as the promising PET tracers have been made rapid development in recent years. There are many methods for 18F-labeled peptides. According to the characteristics of the labeling reactions, this review summarized the methods of 18F-labeled peptide as follows: 1) 18F-labeled prosthetic group method; 2) solid-phase labeling method; 3) 18F-AlF labeling method; 4) click reaction; 5) 18F-19F isotope exchange method; 6) aromatic electrophilic or nucleophilic labeling method; 7) the other labeling methods. Furthermore, these methods’ advantage and disadvantage were analyzed.
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