Study on Synthesis of 15N- Hydrazine Hydrate
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Abstract
The 15N labeled hydrazine hydrate is a strong reducing agent in the synthesis procedure of stable isotope labeled compounds, and it has been widely used in the isotope-labeled pharmaceutical synthesis. The reaction conditions of 15N labeled hydrazine hydrate were mainly investigated by single-factor design, and the following optimized conditions were obtained: the concentration of available chlorine was 115-120 g/L, the chlorination reaction time was 30~40 min, the reflux time was 7 min, and the mass ratio of material was m(catalyst) ∶m(urea) =1.0∶10.0, and the yield of 15N labeled hydrazine hydrate was 76.1%, the abundance of 15N was 99.20%.
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