The Research on Biodistribution of Bearing Sarcoma Mice and Rabbit SPECT Imaging of ¹⁷⁷Lu-DOTMP

Cyclen(1,4,7,10-tetraazacyclododecane) and H₃PO₃ were used to synthesis DOTMP(1,4,7,10-tetraazacyclododecane-1,4,7,10-Tetraaminomethylenephosphonate)， and then DOTMP was labelled with ¹⁷⁷Lu.The research of biodistribution of ¹⁷⁷Lu-DOTMP in model mice bearing S180 sarcoma and SPECT imaging in Japanese white rabbit were also carried out. The results of biodistribution of bearing S180 mice indicated that ¹⁷⁷Lu-DOTMP cleared rapidly from blood and was selectively delivered to target bone. The radioactivity uptake was mainly in bone and less in other organs and tissues. The results of SPECT imaging of Japanese white rabbit showed that the radioactivity was accumulated in bladder. ¹⁷⁷Lu-DOTMP was mainly excreted by kidney. The uptake of the activity in the skeleton was observed significatantly within 22 h postinjection and it became quite significant at 46 h post-injection. It indicated that ¹⁷⁷Lu-DOTMP has good bone targeting and is worthy of further study.