Synthesis of Deuterated Phencynondte Hydrochloride

The experimental details for the preparation of phencynondte labelled with five deuteriums with high chemical purity and isotopic enrichment were researched. Deuterated intermediate compound α-cyclopentyl-α-D₅-phenyl-glycolate was synthesized first by Grignard reaction from bromobenzene-d5, the final product deuterated phencynondte hydrochloride was then prepared through next three steps reaction with excellent chemical purity and isotopic enrichment. D abundance of synthetic deuterated phencynondte hydrochloride was 99%, the compound was identified by MS and ¹H-NMR.