Imaging and Effect of 131I-histamine-indomethacin in SPECT for Rat’s Lewis Pulmonary Tumor Model
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Abstract
In order to observe the Visualization of SPECT and therapeutic effect of 131I-histamine-indomethacin(131I-His-IN) in rat’s Lewis pulmonary tumor model, rats with Lewis pulmonary tumor were gavaged with 131I-His-IN. The results showed that 131I-His-IN radioactive nuclide rate of tumor area to other area step up as the time goes by, and the necrotic tissue and cells become more and more. These suggested that 131I-His-IN was an effective imaging agent which can diagnosis the primarily focus and the distant place metastasis of the tumor and do the internal radiation of the tumor.
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