Semi-automated Synthesis of 1-18Ffluoroethyl-L-tryptophan
-
-
Abstract
A novel 18Ffluoro amnio acid analogue 1-18Ffluoroethyl -L- tryptophan (1-18FFETrp) was designed and synthesized. The cold standard 1-19FFETrp was synthesized by sevenstep reactions, starting from tryptophan. Then fluoromultifunctional chemistry process control unit (CPCU) was used to synthesize 1-19FFETrp by nucleophilic fluorination. 1-18FFETrp was synthesized in a twostep semiautomated procedure. The no decay corrected radiochemica1 yield of 1-18FFETrp was 1.5% within 50 min total reaction time. Further experimental work is needed to improve the radiochemical yield, with the hope of attaining a satisfacting new PET imaging agent for differentiating the tumors and inflammation.
-
-