Synthesis, biodistribution of animal and MicroPET Imaging of O-(2-18Ffluoroethyl)-5-hydroxy-L-try- ptophan (5-18FEHTP)

5-18FEHTP was synthesized by using a modified chemistry process control unit (CPCU). Radiochemical purity was over 98% measured by High Performance Liquid Chromatograph (HPLC). After injecting of 5-18FEHTP through tail vein, the mice was scanned with Micro PET. The no decay corrected radiochemical yield of 5-18FEHTP was 12-16% (n=15) within 45min total reaction time, and the manually purified time was about 20min. 5-18FEHTP can be conveniently synthesized with modified CPCU and the labeling yield was stable, the results of Micro PET imaging indicated that 5-18FEHTP may be a new promising PET tracer.