Radiosynthesis of N-succunimidy-4-18F-Fluorobenzoate using Siemens Chemistry Process Control Unit (CPCU)

The objective of this research was to synthesize the N-succunimidy-4-18F- Fluorobenzoate (18F-SFB), which is used as the prosthetic groups for the 18F labeling of bimolecular like proteins, mono-antibodies and peptides, using the modified Chemistry Process Control Unit (CPCU). The CPCU was modified, we synthesized 18F-SFB using the ethyl-4-trimethyammonium-benzoate triflate as precursor. And the radiochemical purity of the products was measured by High Performance Liquid Chromatograph (HPLC). The total synthesis time was 80 min after EOB. The decay-corrected radiochemical yield of 18F-FBA was 80±5% (n=8) and that of 18F-SFB was 40±5 % (n＝20). The radiochemical purity was more than 99%. Thus, 18F-SFB can be conveniently synthesized with modified CPCU and the labeling yield was stable, which was easily used for the labeling of bioactive compounds.