Preparation of 99mTc-Memantine as a Novel Brain Receptor Imaging Agent and Its Lyophilized Kit

The precursor of compound II N2S2-Memantine was synthesized. N2S2-Memantine was labeled with 99mTc by using stannous fluoride as reducing agent，and the labeling conditions of I 99mTc（V）- Memantine were optimized， and lyophilized kit of 99mTc（V）- Memantine was also developed. The labeling yields in excess of 90% and radiochemical purity more than 95% by the TLC analyses. The product was good stability in room temperature. 99mTc（V）- Memantine would be a potential brain receptor imaging agent which would need more research work.