Carbon-11 labelled Thioflavin T derivative for Aβ-Amyloid imaging

The synthesis of 2-(4-aminophenyl)benzothiazole (APBT) was reported. The carbon-11 labeled APBT was performed by improved-methods with 11C-methyl iodide. The labeled yield was measured with column-methods. The results showed that the column-methods for labeled yields was simple and efficient. The improved-methods led to radiochemistry yield of 58%(n=10) when 11CCH3I react with APBT. Intravenous injection of 11C-BTA-1 in control mice resulted in high brain uptake. The brain uptake was 3.810.34%/ID at 2min. The uptake ratio of 2/30min was 10. 11C-BTA-1 was a promising -amyloid agent for Alzheimer’s disease.