Effects of high iodine-containing diet on 99TcmO4- uptake in mice
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Abstract
KM mice were fed with various dose iodine containing diet for 1 week, and then, injected into 37 MBq 99 Tc mO - 4, 99 Tc m uptake were mearsured at different time, the main aim is to study the effects of high Iodine containing diet on 99 Tc m uptake of thyroid. 99 Tc m uptake were mearsured at the different time. Contrast analysis of the date were done by the Dunnett t test and SNK q test. Compared with the control group, the significant differences were found at different time between high iodine containing and normal diet groups at the time of 10, 20 and 60 min( t 1,0( 10 min) =7.364, t 2,0( 10 min) =6.807, t 3,0( 10 min) =6.674, t 4,0( 10 min) =5.594; t 1,0( 20 min) =9.843, t 2,0( 20 min) = 9.730, t 3,0( 20 min) =9.132, t 4,0( 20 min) =9.128; t 1,0( 60 min) =5.958, t 2,0( 60 min) =8.292, t 3,0( 60 min) =8.147, t 4,0( 60 min) = 6.358 P< 0.01). But at the time of 30 min, there is no significant difference for 99 Tc mO - 4 uptake between the control group and the high iodine containing diet group. All the results show that high iodine containing diet depressed the function of 99 Tc mO - 4 uptake in the thyoid of mice.
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