Preparation of ¹⁸F-FDG by Basic Hydrolysis on “1-Pot” FDG Synthesis Module

“ 1 pot” equipment is an automatic synthesis module of producing  ¹⁸ F FDG by acid hydrolysis process. Simple changes in the chemistry, plumbing, and programming of CPCU enable two back to back “ 1 pot” systems in a unit. The preparation of precursor of  ¹⁸ F FDG is the same with origin. The results of experiments showed that by basic hydrolysis procedure, the synthesis time is shorten from 45 50 min to 30 35 min, uncorrected synthesis yield can be increased from 45% 50% to 60% 65%, and the preparing procedure is stable. The quality of  ¹⁸ F FDG meets the requirements under USP fludeoxyglucose  ¹⁸ F injection, radiochemical purity is more than 99% especially by HPLC. With “ 1 pot” FDG synthesis module Chemical Processing Control Unit (CPCU),  ¹⁸ F FDG can be prepared by basic hydrolysis process.