Absorption Distribution and Excretion of ⁶³Ni-NiCl₂ in Rat

The uptake, distribution and excretion of  ⁶³ Ni NiCl ₂ in rat were studied by liquid scintillation counting method. It was observed that the concentration time curves in blood fitted the two dicompart ment model of pharmacokinetics,  K _a=6.18 h,  T _1/2(α ) =0.79 h,  T _1/2(β ) =40.68 h, CL=0.42 mL· kg ^-1· h ^-1 ,  T _peak =0.53 h, C _max =14.99 GBq/L,  V_d = 0.016 L/kg.  ⁶³ Ni NiCl ₂ was existed in all of 12 tissues tested; at 0.25 h, radioactivity in intestine were the highest, and that in stomach and fattiness were higher; at 3 h, liver, stomach and intestine were higher; the germen was the least; The liver and lung was the higher at 24 h. In 24 h 83.26% of radioactivity of oral administration was eliminated by urine and feces, 54.86% by urine, 28.41% by feces.