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Lian ZHOU, Shi-neng LUO, Xue-hua GUO, Ming-hao XIE, Hong-yong WANG, Ya-ling LIU, Pei ZOU, Yong-jun HE. Study on the preparation and biodistribution of 99Tcm-DTPA-di (3，5-dimethoxy-4′-aminostilbene)[J]. Journal of Isotopes, 2007, 20(2): 68-73. DOI: 10.7538/tws.2007.20.02.0068
Citation: Lian ZHOU, Shi-neng LUO, Xue-hua GUO, Ming-hao XIE, Hong-yong WANG, Ya-ling LIU, Pei ZOU, Yong-jun HE. Study on the preparation and biodistribution of 99Tcm-DTPA-di (3，5-dimethoxy-4′-aminostilbene)[J]. Journal of Isotopes, 2007, 20(2): 68-73. DOI: 10.7538/tws.2007.20.02.0068
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Study on the preparation and biodistribution of 99Tcm-DTPA-di (3，5-dimethoxy-4′-aminostilbene)

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  • DTPA-di (3,5-dimethoxy-4′-aminostilbene)(3)was synthesized by the incorporation of 3,5-dimethoxy-4′-aminostilbene (1) into DTPAA. The structure was confirmed by IR, MS, 1HNMR and element analysis. It was labeled with 99Tcm and the biodistribution in rats was also studied. The results showed that the labeling yield was over 90％ and the labeled compound was high concentration in liver and rapid clearance in lung and blood.
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