Study on the Pharmacokinetics of rhPTH_1-34 in Sprague-Dawley
Rats by ¹²⁵I Tracing

125I tracing method is used to observe the pharmacokinetic parameters of the recombinant human parathyroid hormone (1-34) (rhPTH1-34) in adults Sprague-Dawley rats. The results show that when adults SD rats is given a dosing regimens of 1.8 and 3.6μg/kg rhPTH1-34 by single dose subcutaneous, the main pharmacokinetic parameters of rhPTH1-34 including Tmax, Cmax, T1/2el and AUC is 0.26±0.07h, 0.25±0.0h; 1.30±0.17 μg/L, 3.20±1.12μg/L; 1.70±0.56h, 1.58±0.70h and 3.1±0.7 μg•h /L,6.7±0.7μg•h /L, respectively. It shows that the pharmacokinetic characteristics of rhPTH1-34 in SD rats is accord with linear one-compartment model and eliminate with mono-phase kinetics.