Synthesis of DTPA-2SN and Its Labeling With ⁹⁹Tc^m

Diethylenetriaminepentaacetic acid bianhydride (DTPAA) is prepared at first, and then DTPA-2SN is synthesized by the incorporation of sulfanilamide (SN) into DTPA，and labeled with 99Tcm. The analysis results of DTPAA and DTPA-2SN are in accord with their molecular structure. DTPA-2SN is easy labeled with 99Tcm, the highest labeling rate of product reach up 90%±3%.and its radiochemical purity is ＞95 after purified by Sep-Pak C18 cartridge. 99Tcm-DTPA-2SN shows high stability in vitro, its radiochemical purities is more than 90% at 4 h in room temperature. It indicates that 99Tcm-DTPA-2SN can be used for animal experiment.