Preparation of 99mTc-ciprofloxacin Kit and its Biodistribution

Ciprofloxacin (CPF) made in China is labeled with 99Tcm and the factors affecting the labeling efficiency are determined. Accordingly, a new CPF cold kit is developed and the biodistribution of 99Tcm-CPF in infected animal is evaluated. Under the optimal condition of pH 3.0～3.5, CPF contents above 4 mg, SnCl2•2H2O contents over 100μg, 10 minutes after injection of 99TcmO4-, the radiochemical purity of 99Tcm-CPF is above 95% and remained >95% at 6 h after preparation at room temperature. The kit is stored at 0~8℃ or at -18℃ in refrigerator, theradiochemical purity of 99Tcm-CPF keeps up with over 95% after 3 months. Mice with infectious lesions injected with 99Tcm-CPF show a mean abscess-to-muscle ratio of 4.30±0.31at 4h post injection.