A Pilot Study of Semiautomatic Synthesis Module for Preparing Multiple Fluorine-18-labeled Radiopharmaceuticals

To improve FDG synthesis module Chemical Processing Control Unit(CPCU) manufactured by CTI for producing ~(18)F-FLT and ~(18)F-FECh,the ~(18)F-FDG module is modified.Additional devices are designed and added for performing the purification of fluorine-18-labeled radiopharmaceuticals.Repeated experiments show that the radiochemical yields of ~(18)F-FLT and ~(18)F-FECh are(37.3±3.1)% and(37.2±4.7)%,and three times and one time higher than manual operation as well,the total synthesis time is shorten to 50 minutes and 45 minutes respectively.Radiochemical purities of both ~(18)F-FLT and ~(18)F-FECh are more than 98%.Multiple fluorine-18-labeled radiopharmaceuticals can be prepared by using the semiautomatic synthesis device.