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Pharmacological Study of ~(99)Tc~m-CO-MIBI,a New Myocardial Perfusion Imaging Agent Comparison to ~(99)Tc~m-MIBI[J]. Journal of Isotopes, 2005, 18(4): 220-220. DOI: 10.7538/tws.2005.18.04.0220
Citation: Pharmacological Study of ~(99)Tc~m-CO-MIBI,a New Myocardial Perfusion Imaging Agent Comparison to ~(99)Tc~m-MIBI[J]. Journal of Isotopes, 2005, 18(4): 220-220. DOI: 10.7538/tws.2005.18.04.0220
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Pharmacological Study of ~(99)Tc~m-CO-MIBI,a New Myocardial Perfusion Imaging Agent Comparison to ~(99)Tc~m-MIBI

  • ZHAO Jian-dong~1,WANG Jin-cheng~1,MI Hong-zhi~1,HAO Gui-yang~2,ZHU Lin~2(1.Department of Nuclear Medicine,Beijing Anzhen Hospital,Beijing 100029,China

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  • Received Date: April 25, 2005
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    • Abstract
  • Pharmacological experiment of ~(99)Tc~m-MIBI and ~(99)Tc~m-CO-MIBI are performed by self-contrast in dogs.The data of pharmacokinetics parameters,biodistribution,T/NT are collected and calculated during and after photograph.Moreover,the whole body image,heart plane scintigraphy and tomography are investigated.Blood-pool clearance of ~(99)Tc~m-CO-MIBI conforms to two-compartment with 436.36±54.77 mL/h of blood clearance(CL) and T_(α(1/2))=1.46±0.13 min for the fast early clearance,T_(β(1/2))=97.30±20.50 min for the slow late clearance,which faster than that of ~(99)Tc~m-MIBI.The time-radioactivity curves show that the hepatic uptake curves are below the heart curves at about 40 min after ~(99)Tc~m-CO-MIBI injecting.The heart-lung and heart-liver ratios,which are measured at several time points,also demonstrate that ~(99)Tc~m-CO-MIBI have higher uptake and longer retain in myocardium,lower lung radioactivity and faster excrete from liver compare to ~(99)Tc~m-MIBI.During 10-120 min after ~(99)Tc~m-CO-MIBI injected,the excellent plane and SPECT can be obtained,perfect myocardial image without liver activity disturbance are gained after 40 min injecting.It suggests that ~(99)Tc~m-CO-MIBI have better pharmacokinetics properties and offer a great possibility as a new myocardial perfusion image agent.
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    • References (4)
  • [1]
    Alberto R,Ortner K,Wheatley N,et al.Syn-thesis and Properties of Boranocarbonate:a Con-venient in Situ CO Source for the Aqueous Prepa-ration of[99Tcm(OH2)3(CO)3]+[J].J AmChem Soc,2001,123:3 135-3 136.
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    王金城,刘伯里,米宏志,等.心肌显像剂[99Tcm(CO)3(MIBI)3]+和99Tcm-MIBI药理实验对比研究[J].中华核医学杂志,2002,22(4):231~232.
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