Synthesis and ~(125)I Labeling of N-Succinimidyl-3-(tri-n-butylstannyl)benzoate

N-succinimidyl-3-(tri-n-butylstannyl)benzoate(ATE) and N-succinimidyl-3-iodobenzoate(SIB) is synthesized.The structures of ATE and SIB are confirmed with ~1HNMR,MS and IR.The yields of ATE and SIB are 45.4% and 71.4%,respectively.ATE is labeled with ~(125)I.The labeling field is 93.0% and radiochemical purity is over 98.0%.The synthesis and the labeling of ATE has a important value for indirect label of radiopharmaceuticals.