The Detection of Serum Homcysteinet(Hcy) Level in Ⅱ Diabetes Mellitus With Hyperinsulinism

To explore the relationship between serum tatal homocysteine(Hcy) level and Ⅱ diabetes mellitus(DM) with hyperinsulinism and insulin resistance, serum total Hcy level in 30 normal subjects and 78 type Ⅱ DM(38 with hyperinsulinism) are detected. The results show:the mean serum Hcy level is 11.90±3.90 μmol/L, 9.21±2.83 μmol/L at oral glucose tolerance test(OGTT) 1 h and 10.43±3.82 μmol/L at OGTT 2 h in normal subjects (n=30); 21.80±7.98 μmol/L, 17.98±6.83 μmol/L at OGTT 1 h and 12.58±6.73 μmol/L at OGTT 2 h in DM without hyperinsulinism and angiopathy(n=40); and 19.80±7.98 μmol/L, 14.50±7.69 μmol/L at OGTT 1 h and 11.07±6.52 μmol/L at OGTT 2 h in DM with hyperinsulinsm (n=38).The Hcy level is a significant difference among three groups (P<0.001,P<0.01). Hcy level of DM with hyperinsulinism is lower than that of DM with hyperinsulinism(P<0.01). The serum Hcy level in DM is higher than that in control group, the elevated level of serum Hcy may be related to the diabetic hyperinsulinism and insulin resistance.