The Preparation of ~(153)Sm-glucoheptonate

Influences of labeling conditions on the formation of glucoheptonate (GH) labeled with 153Sm and in vitro stability of 153SmGH are investigated. The effective labeling method of GH labeled with 153Sm is established. The results show that the labeling yield of 153SmGH is more than 98% using an open nitrogenpouring labeling system heated in boiling water bath with reactive time not less than 30 min, concentration of GH more than 2.4×10-2 mol/L. The specific activity of 153SmGH is up to 14 GBq/g(GH) using 153SmCl3 with the high specific activity of 153Sm (～4.5 TBq/g(Sm)). 153SmGH can remain well with its radioactive chemical purity more than 96% within 40 hours at room temperature.