Clinical Significance of Serum Laminin in the Patients With Diabetic Nephyropathy

The concentration of serum LN is determined by radioimmunoassay in 78 diabetic patients and 30 normal subjects as control. The mean concentration of LN in total 78 diabetic patients is higher than that of control, especially in group B and group C are remarkablely higher as comparable with control (P<0.01). There is significantly positive correlation between serum LN and diabetic duration, UAE,FBG. The results show that abnormal laminin metabolism exists in diabetic patients. The increased serum LN level in diabetic patients related to the severity of dibetic renal lesion and could be an early and sensitive marker of DN.