The Changes of IL-8、IL-10、IL-12 and IgE in Serum of Patients With Asthma

To evaluate the relationship and the clinical significance between the serum IL8?IL10?IL12 and IgE in patients with asthma, the serum IL8, IL10 are measured by radioimmunolassay method and the serum IL12, IgE by ELISA in 55 patients with asthma. The level of serum IL8?IgE at stage of episode are significantly higher than that at stage of remission(P<0.01); the level of serum IL10,IL12 at stage of episode are signicantly lower than that at stage of remission(P<0.01). Linear regression shows that the decrease of IL12 relate to the increase of IgE. The results suggests that the change of the level of serum IL8?IL10?IL12 and IgE could be maker for the aggravation of asthma.