The Liver Taxis of Receptor Mediated Lactosaminated Human Growth Hormone

Radiography imaging is used to assess liver taxis mechanism of antidwarfism drug lactosaminated human growth hormone (LrhGH). Both LrhGH and rhGH labelled with 131I are to study their biodistribution in animals(including rabbits, cocks and rats). The results show that LrhGH is of specific hepatic targeting property, and the maximun hepatic concertration rate is 76.8%, which is two times of rhGH. Its hepatic binding is receptor mediated. 