Preparation and Biodistribution of ~(99)Tc~m-HEDTMP

HEDTMP (N(2hydroxyethyl) ethlenediamine1,1,2tri(methylene phosphonic acid)) is labeled with 99Tcm. The stability, rabbit bone imaging and mice biodistribution of 99TcmHEDTMP are investigated. The stability studies show that99TcmHEDTMP is stable in 5 h. The biodistribution indicate 99TcmHEDTMP is mainly concentrated on animal skeleton and the uptake of nontarget tissue is low. The results show that 99TcmHEDTMP is a potential promising bone imaging agent.