Study on Ca~(2+) Antagonistic Effect and Mechanism of Chinese Herbal Drugs Using ~(45)Ca

The Ca2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by 45Ca. The results indicate that potential-dependent Ca2+ channel (PDC) and receptor-operated Ca2+ channel (ROC) in cell membranes of smooth muscle can be blocked by vseveral Chinese herbal drugs, including as Crocus sativus L., Carthamus L., Di-ao-xin-xue-kang(DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions.