Synthesis of 2-~（18）F-fluoro-2-deoxy-β-D-glucose Using Ultrasound Promoted Method

fluoro 2 deoxy D glucose( 18 F FDG) is synthesized using ultrasound promoted method(UPM). The results show that the 2 nucleophilic substitution of F ion has relationship with phase transter catalyst and reaction temperature. The ultrasoundpromoted nucleophilic substitution reaction can finish 70% under 84 ℃ for 10 min without catalyst, 85% under 22 ℃ for 10 min with 10 mg catalyst and 95% under 84 ℃ for 2 min with 10 mg catalyst. Comparing with CTI method, the utilization of F ion of UPM improves 10% and the radioactivity absorption on vessel decreases 5%. The EOS is 60% and EOB is 78% in synthesis time of 40 min using UPM. The free F ion of 18 F FDG is lower than 1% after one C 18 colum purification. So 18 F FDG synthesis yield can be proved obviously using UPM.