DETECTING THE EXPRESSION OF SUBTYPE OF HUMAN SOMATOSTATIN RECEPTOR USING IN SITUS HYBRIDIZATION HISTOCHEMICAL TECHNIQUE

In situs hybridization histochemical technique is applied to detect the expression of five subtype of human somatostatin receptor Mrna (hSSTR1~5), including the expression model of 54 cases of various tumor specimen and the expression density of 24 lung cancer cases. The results indicate that hSSTR1~5 is expressed in tumor in varying degrees, and is not found in normal tissues, hSSTR1~5 is expressed differently in varying tumor tissues. So it is potential to select the specific somatostatin analogue as the carrier of radionuclide for diagnosis tumor with imaging and tumor therapy directly.