RADIOIMMUNOIMAGING OF ARTERIAL AND VENOUS THROMBI IN RABBIT MODEL USING 99 Tc m LABELED MONOCLONAL ANTIFIBRIN ANTIBODY

The anti fibrin McAb SZ 63 is labeled by using the method of 2 iminothiolane modification and 99 Tc m glucoheptonate(GH) transchelation. The experimental femoral arterial and venous thrombi are prepared in rabbits, then 99 Tc m SZ 63 is injected into ear edge vein and imaged by SPECT. 99 Tc m labeled murine IgG is used as a negative control. The old arterial and venous thrombi in rabbits are clearly imaged 2 to 4 h after injection of 99 Tc m SZ 63. McAb SZ 63 would be a potential agent for diagnosis and therapy of thrombotic disease.