DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY

doi:10.7538/tws.1992.05.04.0198

Journal of Isotopes > 1992 > 5(4): 198-198. > DOI: 10.7538/tws.1992.05.04.0198

DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY[J]. Journal of Isotopes, 1992, 5(4): 198-198. DOI: 10.7538/tws.1992.05.04.0198

Citation:

DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY[J]. Journal of Isotopes, 1992, 5(4): 198-198. DOI: 10.7538/tws.1992.05.04.0198

Citation:

DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY[J]. Journal of Isotopes, 1992, 5(4): 198-198. DOI: 10.7538/tws.1992.05.04.0198

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DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY

Xu Rongzhu (Computing Center,Ministry of Foreign Economic Relations and Trade of the People. s Republic of China,Beijing 100011) Masatake Ohkubo (Radionuclide Metroloqy Division Department of Radioisotopes, Japan Atomic Energy Research Institute, 319—11)

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Received Date: March 10, 1992

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Abstract

Abstract

Ion chromatography was applied to establish a quick and reliable procedure for copper analysis at less than 10~(-6)level for the determination of the specific activity of ~(64)Cu products prepared by Szilard Chalmers process of Cu-phthalocyanine. The ion chromatographic system consisted of a low capacity cation-exchange column,postcolumn-reaction system, a spectrophotometric detector and a data processor. Eluted Cu (Ⅱ)was detected by measuring the absorbance of Cu-2-(2-pyridylazo) resorcinol complex at 520 nm. The optimum condition for the separation of Cu(Ⅱ)from five transition metal ion; Fe(Ⅱ,Ⅲ), Ni(Ⅱ),Zn(Ⅱ),Co(Ⅱ)and Pb(Ⅱ), was examined using two types of eluents; (1) a mixture of 6 mmol 2-pyridine-5-dicarboxylic acid(PDCA), 50 mmol sodium acetate and 50 mmol acetic acid solutions,and (2) 50 mmol oxalic acid solution. A separation coefficient for Cu(Ⅱ)to Ni (Ⅱ)was used to select a suitable eluent for the separation of Cu(Ⅱ). Effects of the flow rate and pH of eluent, concentration of PAR, and the wavelength used for measuring absorbance of Cu-PAR complex on the peak area were examined. The best condition determined was: eluent:mixture of 6 mmol PDCA, 50 mmol acetic acid, and 50 mmol sodium acetate; pH: 4.81; flow rate: 1 ml/min wavelength: 520 nm. Analysis of standard samples containing Cu(Ⅱ)and other metal ions showed that this method is precise, accurate and rapid for the determination of Cu (Ⅱ). The specific activities of ~(64)Cu products determined by using the present method and by conventional spectrophotometric method were compared.
- post column reagent PAR 4-(2-phyridylazo) resorcinol,
- high performance ion chromatographyultra-violet/visible detectorHPIC-CG5 and HPIC-CS5 columns.

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[1]	Ohkulo M, Terunuma K, Kushita K, et al. The Chemical Inspection Manual for Radioisotope Products. JAERI-memo 1983, 58．
[2]	Barns R K, Boots D and Sorby P J. Polarographic Quantification of the Specific Activity of Copper-64 Produced by Szilard-Chalmers Reactions. Appl Radiat Isot, 1986, 37: 1241．
[3]	Small H, Gtevens T S and Bauman W C. Novel Ion Exchange Chromatographic Method Using Conductimetric Detection. Anal Chem, 1975, 47: 1801．
[4]	Kreling J R and Jack Dezwaan. Ion Chromatographic Procedure for Bicarbonate Determination in Biological Fluids. Anal Chem, 1986, 58: 3028．
[5]	Jenke D. Determination of Alkaline-Earth Metals in Samples Containing a Large Excess of Alkali by Ion Chromatography. Anal Chem, 1987, 59: 624．
[6]	Cox J A. Determination of Anions in Polyelectrolyte Solutions by Ion Chromatography after Donnan Dialysis Sampling. Anal Chem, 1987, 59: 534．
[7]	Nonomura M. Indirect Determination of Cyanide Compounds by Ion Chromatography with Conductivity Measurement. Anal Chem, 1987, 59: 2073．
[8]	Strong D L and Dasgupta P K. Electrodialytic Membrane Suppressor for Ion chromatography. Anal Chem, 1989, 61: 939．
[9]	Knight C H, Cassidy R M, Recoskie B M, et al. Dynamic Ion Exchange Chromatography for Determination of Fissions in Thorium-Uranium Dioxide Fuels. Anal Chem, 1984, 56: 474．
[10]	Cassidy R M, Elchuk S, Elliot N L, et al. Dynamic Ion Exchange Chromatography for the Determination of Number of Fissions in Uranium Dioxide Fuels. Anal Chem, 1986, 58: 1181．
[11]	Fritz J S and Story J N. Chromatographic Separation of Metal Ions on Low capacity Macroreticular Resins. Anal Chem, 1974, 16: 825．
[12]	Fortier N E and Fritz J S. Separation and Determination of Aluminium by Single-Column Ion-Chromatography. Talanta, 1985, 32: 1047．
[13]	Zenki M. Determination of Alkaline Earth Metals by Ion-Exchange Chromatography with Spectrophotometric Detection. Anal Chem, 1981, 53: 968．
[14]	Geddes A F and Tarter J G. The Ion Chromatographic Determination of Cr (Ⅱ)-Cr(Ⅵ) Using an EDTA Eluant. Anal Letters, 1988, 21 (5): 857．
[15]	Hetherington E L, Sorby P J and Camakaris J. The Preparation of High Specific Activity Copper-64 for Medical Diagnosis. Appl Radit lsot, 1986, 37: 1242．

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DETERMINATION OF TRACE AMOUNTS OF COPPER AND IMPURITIES IN RADIOACTIVE ~(64)Cu PRODUCTS BY ION CHROMATOGRAPHY

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