~(99)Tc~m-LABELLED ANTIBODIES FOR RADIOIMMUNOIMAGING OF TUMORS

This overall review concerns the preparation, present preliminarily clinical test results, and its future application of ~(99)Tc~m-labelled antibodies (~(99)Tc~m-Abs) for tumor radioimmunoimaging (RII). Techniques of radiolabelling antibodies with ~(99)Tc~m by both direct and indirect methods are summarized. Factors related the clinical application of ~(99)Tc~m-Abs; including antibody preparation, radiolabelling techniques, radiopharmakinetics etc., are analysed, and several new potential ways for successful RII using ~(99)Tc~m-Abs are recommended.