Synthesis of ~(14)C-Dehydrocorydaline chloride

Synthesis of ~(14)C-Dehydrocorydaline chloride[J]. Journal of Isotopes, 1988, 1(1): 42-42. DOI: 10.7538/tws.1988.01.01.0042

Citation:

Synthesis of ~(14)C-Dehydrocorydaline chloride[J]. Journal of Isotopes, 1988, 1(1): 42-42. DOI: 10.7538/tws.1988.01.01.0042

Citation:

Synthesis of ~(14)C-Dehydrocorydaline chloride[J]. Journal of Isotopes, 1988, 1(1): 42-42. DOI: 10.7538/tws.1988.01.01.0042

Abstract

In this paper, a method for synthesis of ~(14)C-dehydrocorydaline chloride is described. In the presence of sodium hydroxide, acetonylpalmatine is reacted with ~(14)C-methyl iodide in sealed glass ampoule to give ~(14)C-13-methylpalmatine iodide which is then coverted to chloride. The radiochemical purity of ~(14)C-dehydrocorydaline determined by TLC is over 98％ and the labelling efficiency is 540％.

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