Abstract:
The radiolanthanide
161Tb has garnered increasing interest due to its favorable properties for medical application.
161Tb showed similar properties to the widely used therapeutic radionuclide
177Lu, and had better curative effect, which was expected to replace
177Lu as a new type of therapeutic radionuclide. So far, the studies on the application of
161Tb have mainly focused on the basic in vivo behavior of
161Tb-labeled biomolecules and their effects on malignant tumors compared with
177Lu. These preliminary therapeutic studies show that
161Tb was more effective than
177Lu in tumor treatment if the same activity was used. The characteristics, production and research progress of labeled radiopharmaceuticals of
161Tb are reviewed, which can provide reference for the development and clinical application of therapeutic radionuclides.