Abstract: The application of radioisotopes in the industrial field is mainly to use the rays and material interaction to detect the level, density, thickness and other material information, analyze the material composition and irradiation processing. Radioactive isotopes are widely used in industrial fields such as petroleum, chemical, steel, coal, paper making, plastics, resource exploration, lithium battery new energy and aerospace. The main application forms of radioisotopes in industrial applications are sealed radioactive sources and tracers, among which the radioactive sources are mainly used in industrial process detection, irradiation processing, radiation imaging detection, radioactive logging and instrumentation correction, and the tracers are mainly used in the tracer of oil field. By summarizing the basic principles and technical methods of industrial application of radioactive isotope application, analyzing the factors and optimization measures affecting industrial application, it is of great significance for the research, design, application and optimization of industrial application technology.