INTRABEAM系统水吸收剂量测量方法比较分析

Comparative Analysis of Water Absorbed Dose Measurement Methods in INTRABEAM System

  • 摘要: INTRABEAM系统作为电子近距离治疗的一种,通过产生低能X射线直接治疗癌症,准确的剂量是实现肿瘤治疗的基础,该系统剂量测量依赖间接测量方法,剂量可溯源性存在不确定性。本研究首先分析INTRABEAM系统的剂量特性,发现在不同水深度x处的剂量变化趋势非常接近x−3,研究比较制造商出厂测量法、Zeiss V4.0方法、TARGIT方法、CQ方法等不同的水吸收剂量测量方法,发现在剂量计算上存在差异。分析水体模散射、光束硬化、防水套材料和厚度对剂量测量结果的影响,以及不同测量条件下的校准因子差异。研究结果表明,制造商给定参考值、TARGIT方法和Zeiss V4.0方法测量值可能均低估了实际水吸收剂量,无法实现剂量可溯源性。目前,建立一个基于绝对测量原理的水吸收剂量测量方法已成为实现剂量可溯源性和治疗精确性的关键。

     

    Abstract: INTRABEAM is a type of electronic brachytherapy that directly treats cancer by producing low-energy X-rays. It has advantages such as precise treatment, ease of operation, and protection of surrounding healthy tissues. The INTRABEAM system is favored in clinical applications for its excellent dose distribution, especially in breast-conserving surgery for breast cancer. Accurate dosimetry is essential for effective tumor treatment. However, the dose measurement of the INTRABEAM system relies on indirect measurement methods, which still faces challenges in achieving dose traceability. This study first analyzes the dose characteristics of the INTRABEAM system. The results show that the dose varies with water depth in an x−3 pattern, highlighting the need for precise dose values at specific points. The study explores methods for measuring water absorption doses. It compares different dose measurement methods, including the manufacturer’s measurement method, Zeiss V4.0 method, TARGIT method, and CQ method, and finds differences in dosimetry. The study also discusses the impact of water phantom scattering, beam hardening, and the material and thickness of the waterproof cover on dosimetry, as well as calibration factors under different measurement conditions. The research results show that the reference values given by the manufacturer, the TARGIT method and the Zeiss V4.0 method may all underestimate the actual water absorbed dose and fail to achieve dose traceability. Therefore, establishing a water absorbed dose measurement method based on the absolute measurement principle has become a key goal to achieve dose traceability and treatment accuracy.

     

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