Abstract: This study focuses on the simulation of target preparation, dissolution, and separation- purification processes for the production of the vital medical radioactive isotope ⁶⁸Ge using medium-high energy cyclotrons. It encompasses the preparation and quality inspection of gallium-nickel alloy targets, target dissolution, the establishment of analytical detection methods, and the optimization of simulation conditions for the separation and purification of ⁶⁸Ge. Initially, gallium-nickel alloy targets were prepared on copper backing plates by optimizing the electrodeposition process conditions. Analytical detection methods were then established using inductively coupled plasma mass spectrometry (ICP-MS). Subsequently, the dissolution process of the gallium-nickel alloy targets was studied using an electrochemical anodic oxidation method. Finally, the combined use of Tulsimer CH-90 chelating resin and Sephadex G25 gel resin was employed to optimize the simulation conditions for the separation and purification of ⁶⁸Ge, completing the process simulation study. The results indicate that the prepared gallium-nickel alloy targets have a smooth and flat surface with a uniform composition distribution, containing 74.7% gallium and 25.3% nickel, and have a thickness of 179 mg/cm², suitable for medium-high energy proton irradiation above 30 MeV. The established ICP-MS internal standard method enables accurate quantitative detection of germanium and impurity elements. The electrochemical method allows for simple and rapid dissolution of the gallium-nickel alloy layer without heating. The combined use of chelating resin and gel resin for separation and purification yields germanium-containing sample solutions with high recovery rates and purity. Through the aforementioned process simulation studies, a simulated process flow for target preparation, target dissolution, analytical detection, and separation-purification has been established, providing technical support for the production of ⁶⁸Ge using medium-high energy cyclotrons.