放射性治疗药物近期研发进展与策略

Recent Advances and Strategies in the Development of Therapeutic Radiopharmaceuticals

  • 摘要: 放射性治疗药物可用于多种肿瘤疾病的治疗,其全球市场份额在最近十年或将发生爆发性增长。另一方面,近期我国核医学出现放射性治疗药物靶点同质化严重、在研新药缺乏原创性靶点的问题。临床研究是新药开发的关键步骤,其研究进展集中体现了放射性治疗药物发展趋势与创新方向。因此,基于放射性治疗药物的主要模块,重点介绍新药临床研究的近期进展,主要包括药物作用机制与靶向策略、治疗用放射性核素的临床应用、疾病靶点及靶向配体的临床评价。同时,总结治疗用核素的研发难点与应对策略,归纳放射性治疗药物的研究趋势,并展望我国放射性治疗药物的发展契机,为放射性治疗药物研发人员及相关人员提供参考。

     

    Abstract: Therapeutic radiopharmaceuticals can be employed in the treatment of various tumor diseases, and their global market share is likely to witness an explosive growth in the recent decade. On the other hand, a significant issue in China’s nuclear medicine field is the severe homogeneity of therapeutic radiopharmaceuticals targets recently, coupled with a deficiency in original targeting agents for newly developed radiopharmaceuticals. Clinical research is a crucial step in the development of new drugs, and its research progress centrally reflects the development trends and innovation directions of therapeutic radiopharmaceuticals. Therefore, based on the main modules of therapeutic radiopharmaceuticals, this paper focuses on introducing the recent progress of clinical research on new drugs, mainly including the drug action mechanism and targeting strategies, the clinical application of therapeutic radioisotopes, the clinical evaluation of disease targets and targeted ligands. Simultaneously, this paper summarizes the application difficulties and coping strategies of therapeutic radionuclides, induces the evolution trend of therapeutic radiopharmaceuticals, and looks forward to the development opportunities of therapeutic radiopharmaceuticals in China. It is hoped that the above content can offer meaningful references for practitioners and related professionals engaged in the research and development of therapeutic radiopharmaceuticals.

     

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