Abstract: Rapid and selective separation of ⁹⁹Mo from fission products of high enriched uranium or low enriched uranium targets is a key scientific problem to be solved. Ionic liquid, as a new type of solvent, has received extensive attention in the field of extraction and separation. Ionic liquids show good extraction efficiency and selectivity in the separation and purification of Mo(VI), which have a certain application prospect. In this paper, the application of ionic liquid system in extraction of Mo(VI) was summarized and prospected. The effects of traditional molecular solvent, ionic liquid and different extractants on Mo(VI) extraction efficiency and mechanism were discussed.