Abstract:
With the development of nuclear science and technology, the application of PET medical radionuclides is increasing, and the demand is increasing. But the Ge-Ga generators used to provide
68Ga medical radionuclide are all dependent on imports. In order to carry out the research of Ge-Ga generator technology, we will carry out the pilot experiments of
68Ge production.In the study, the simulated production of medical radionuclide
68Ge based on FLUKA Monte Carlo program. The end of bombardment (EOB) yields of
68Ge with 100 μA, 200 μA and 500 μA beam intensity were calculated by 14 MeV, 30 MeV and 70 MeV proton beams irradiating Ga targets enriched with
69Ga for 1 hour, 12 hours and 24 hours, respectively. The changes of EOB yields and the activity of radionuclides on the targets were analyzed. After 24 hours irradiation by 30 MeV/500 μA proton beam, the EOB yield of
68Ge nuclide is 3.13×10
10 Bq, which is similar to the EOB yield with 24 hours irradiation by 70 MeV/500 μA proton beam, which is 4.54×10
10 Bq. There are fewer radioactive impurities on the target and higher input and output benefit with 30 MeV proton beams. Therefore, the proton energy for
68Ge nuclide production is 30 MeV. The research could provide some theoretical basis and support for
68Ge production pilot experiment and mass production.